Both teams are reeling after disappointing defeats. The Trojans fell to the Oregon Ducks 62-51 on Saturday, while the Sun Devils lost to Oregon State, 36-26.
The Trojans still have a double-digit opening spread by virtue of their home field advantage and a potent offense that did manage to score more than 50 points against Oregon.
USC and Arizona State's matchup has potential Pac-12 South implications down the line, as both teams currently trail the UCLA Bruins (7-2, 4-2) atop the standings. The Sun Devils are a half game back of USC and one game back overall. A win for Arizona State would likely catapult them back into the AP Top 25 conversation and put the hot seat firmly on USC head coach Lane Kiffin.