Oregon struck quickly to open the game, moving the ball 75 yards in one minute as Marcus Mariota completed 4-4 passes for 68 yards. The Ducks finished the drive when De'Anthony Thomas scored on a 16-yard touchdown pass.
The Ducks scored again with just less than five minutes left in the quarter when Mariota hit Josh Huff on a 21-yard touchdown pass to cap another 75-yard drive.
USC's only response came midway through the quarter. Matt Barkley led the Trojans on a 12-play, 66-yard drive, but couldn't find the end zone. Andre Heidari put through a 39-yard field goal to finish the drive.
Oregon racked up 203 yards of offense in the first frame, with Mariota going a perfect 7-for-7 for 117 yards and two touchdowns. Barkley was 8-of-12 for 83 yards and an interception. The first quarter ended with Oregon at USC's 15-yard line.