USC (7-4, 5-4 Pac-12) will be without senior quarterback Matt Barkley, who injured his should in the team's 38-28 loss to the No. 17 UCLA Bruins last Saturday. Freshman Max Wittek will get the start under center. After being a preseason No. 1 in many polls, the Trojans would probably like nothing more than to play the role of spoiler and ruin the Notre Dame's perfect season.
With a win on Saturday, the 11-0 Irish could clinch a spot in the BCS Championship game for the first time in school history. They'll likely rely on their stellar defense to put pressure on the Trojans freshman signal caller who boldly predicted a Trojans upset in a radio interview on Tuesday.
Coming off a 38-0 blanking of Wake Forest last Saturday, Notre Dame is a 7-point favorite over the Trojans.
Kickoff is scheduled for 5 p.m. PT and the game will be televised on ABC.