Richard Jefferson and Manu Ginobli each scored 22 points to help San Antonio hold off the Los Angeles Clippers, 107-95, at the AT&T Center.
Tony Parker provided 21 points and nine assists for the Spurs, who have won 18 straight games against the Clippers.
Rasual Butler scored 18 points and Craig Smith provided 15 off the bench for Los Angeles, which returns home after losing all four games on its just- completed road trip.