Ervin Santana (15-9) gave up three runs -- two earned -- on six hits over six innings to improve to 5-1 over his last six starts. The right-hander also walked four batters and fanned three.
Jeff Larish hit a two-run double for the Athletics, who have dropped five of seven. Vin Mazzaro (6-8) got rocked in 4 1/3 innings, giving up five runs on six hits. The right-hander lost his sixth straight decision.
After stranding the bases loaded in the second, the Angels scored four times in the third inning. Howie Kendrick reached base when he grounded into a fielder's choice and crossed the plate on Abreu's homer to right-center. Matsui hit a two-out single and scored on Napoli's blast to left-center.
Oakland got a run back in the home third. Rajai Davis walked, stole second, and scored on Landon Powell's single.
The A's scored two more runs in the fourth to cut the gap to 4-3. Jack Cust singled and Mark Ellis reached first on Erick Aybar's fielding error. Larish cleared the bases with a double to left-center field. Santana retired the next three batters to keep LA in front.
Los Angeles went ahead by two runs in the top of the fifth. Abreu walked and crossed the plate on Hunter's double for a 5-3 lead.
Oakland loaded the bases with two outs in the home fifth, but Larish struck out to end the threat.
The Angels plated two runs in the seventh to extend their margin to 7-3. Kendrick led off with a double and raced home on Abreu's single. Abreu stole second, advanced to third on a groundout, and scored on Matsui's base hit.
The A's scored a run off Fernando Rodney in the ninth. Coco Crisp led off with a single and moved to second two batters later on Gabe Gross' groundout. Cust followed with a bloop RBI single to left. Ellis' base hit put men on first and second, but Larish grounded out to end the game.
The Athletics and Angels have split 16 games this season...Oakland's last three-game sweep of the Angels took place at the Coliseum from June 29-July 1, 2004...Santana boasts a tremendous 12-3 record over 20 career matchups (18 starts) with Oakland and has been terrific as well at the Coliseum, where he's gone 6-1 in nine starts and a pair of relief efforts...Mazzaro fell to 1-2 lifetime against the Angels.