The Angels in 2011 play 15 games against National League opponents:
- at Mets (June 17-19)
- at Florida (June 20-22)
- at Dodgers (June 24-26)
- vs Washington (June 27-29)
- vs Dodgers (July 1-3)
The Angels are 68-40 against National League foes since 2005.
The interleague schedule for the rest of the American League West is as follows:
Oakland (18): at San Francisco, San Francisco, at Mets, at Philadelphia, Florida, Arizona
Seattle (18): at San Diego, Philadelphia, at Washington, at Florida, Atlanta, San Diego
- Texas (18): at Philadelphia, at Atlanta, Houston, Mets, at Houston, Florida
The Marlins are the only common opponent for all four AL West teams. The Phillies and the Mets each play three AL West teams.