Hideki Matsui belted a two-run homer as part of a 4-for-4 effort at the plate for Los Angeles, which evened this three-game series after losing Friday's opener and has now won six of its last eight contests overall. Ervin Santana (12-8) gave up one run on three hits and four walks in seven innings to win for the fourth time in his last five starts.
The Angels are 7 1/2 games behind the AL West-leading Rangers.
The Angels got on the board in the second. Mike Napoli drew a one-out walk and Matsui crushed the next pitch from Cecil over the right-field wall for his 15th home run of the season.
Howie Kendrick singled to begin the fourth and took third on a one-out double by Matsui. Wilson followed by sending a first-pitch slider over the wall in left.
Toronto trailed 5-1 after Lewis went deep in the fifth, but Wilson followed a two-out single by Matsui in the sixth with another blast to left.
Adam Lind hit a run-scoring groundout in the eighth for the Blue Jays.
Santana is 3-0 against Toronto this season...Bobby Abreu went 2-for-3 with a walk for Los Angeles...Cecil suffered his first loss since June 27. He was 2-0 over his previous six starts...The Angels lead the season series, 6-2...The Blue Jays on Saturday signed pitcher Ricky Romero to a five-year, $30.1 million contract extension with a club option for 2016.