The Trojans are coming off their third straight victory, this time over the Washington Huskies in Washington, 24-14. The Trojans are in first place in the Pac-12 South and haven't lost a game since Sept. 15 at Stanford.
The Buffaloes aren't having as great of a season. Colorado is 1-5 including a 1-2 record in the Pac-12 and are coming off two straight losses to UCLA and Arizona State by a combined score of 93-31. This game against the Trojans begins the gauntlet portion of the Buffaloes schedule as they travel to USC this week, to No. 3 Oregon next week and end it with a visit from No. 20 Stanford on Nov. 3.
The Buffaloes give up a whopping 41.3 points per game and the Trojans have reached the 41+ point plateau twice already this season.
The Trojans opened as 40-point favorites over the Buffaloes.