Due to heavy rainfall in Texas on Saturday, the Los Angeles Angels and the Texas Rangers will play a doubleheader on Sunday, with the Rangers playing for a spot in the American League playoffs and the Angels chasing an AL Wild Card spot.
Greinke is 6-2 with a 3.40 ERA since being traded to the Angels in July.
"We'll see if Zack can get us some length in Game 1 and then we have a chance to have more pitchers that aren't going to have to throw in two games," Angels manager Mike Scoiscia told MLB.com. "I think it just gives us a better chance with Zack in Game 1 to pitch deep into [the game] and get to a certain point, and then we'll see where we are in Game 2."
Darvish is 16-9 with a 3.90 ERA and is 3-1 with a 4.26 ERA in five starts against the Angels this season.
Holland is 4-0 with a 3.77 ERA in his last 10 starts. Santana has pitched less than six innings in eight of his previous 11 starts, going 3-4 with a 7.83 ERA during that stretch. Santana's inability to pitch late into games is why Scoiscia went with Greinke in Game 1.
Game Time: 1:05 p.m. ET
Television Coverage: Fox Sports West
Radio Coverage: KLAA 830, KSPN