Zack Greinke (11-5, 3.87 ERA) takes the bump for L.A., looking to keep the Sox in the cellar. He has pitched well against Boston, posting a 2.10 ERA in his last four starts against the Sox, though he hasn't faced Boston since 2010. Greinke pitched well in his last start, lasting 7.2 innings of one-run ball en route to a victory over the Tigers.
Boston will counter with Jon Lester (8-10, 4.98 ERA), who has a 2.25 ERA over his last three starts, all of them victories after going 0-5 with a 7.49 ERA in his previous seven.
First pitch is set for 7:05 p.m. PT with coverage on Fox Sports West.